Weight Loss Drug Interactions

Weight Loss Drug Interactions See Each Agent’s Prescribing Information for Details Belviq (lorcaserin)1 Belviq may increase exposure to

Possible effects of concomitant administration of Belviq and listed drug

Dextromethorphan and other CYP 2D6 substrates

Serotonin syndrome with: • • • • • • • • • • •

Bupropion Dextromethorphan Lithium Monoamine oxidase inhibitors Selective serotonin reuptake inhibitors Selective serotonin-norepinephrine reuptake inhibitors St. John’s Wort Tramadol Tricyclic antidepressants Triptans Tryptophan

Contrave (naltrexone/bupropion)2 Contrave may increase concentrations of

Exposure to bupropion component of Contrave may be increased by

Possible effects of concomitant administration of Contrave and listed drug

Avoid concomitant use of Contrave and

Beta blockers

Carbamazepine

Alcohol

Haloperidol

Clopidogrel

Risperidone

Efavirenz

Amantadine: central nervous system toxicity

Selective serotonin reuptake inhibitors

Lopinavir

Thioridazine

Phenytoin

Tricyclic antidepressants Type 1C antiarrhythmic agents (eg, propafenone and flecainide)

Phenobarbital

Ritonavir Ticlopidine

Levodopa: central nervous system toxicity Monoamine oxidase inhibitors: increased risk of hypertension

Carbamazepine Efavirenz Lopinavir Phenobarbital Phenytoin Ritonavir

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Weight Loss Drug Interactions See Each Agent’s Prescribing Information for Details Qsymia (phentermine/topiramate)3 Exposure to topiramate component of Qsymia may be decreased by

Possible effects of concomitant administration of Qsymia and listed drug

Avoid concomitant use of Qsymia and

Carbamazepine

Alcohol: potentiate CNS depressant effects

Alcohol

Phenytoin

Carbonic anhydrase inhibitors (eg, acetazolamide, dichlorophenamide, zonisamide): metabolic acidosis, kidney stones

Carbonic anhydrase inhibitors (eg, acetazolamide, dichlorophenamide, zonisamide)

Non-potassium sparing diuretics: potentiate hypokalemia Oral contraceptives: irregular bleeding

Monoamine oxidase inhibitors (contraindicated)

Valproic acid: hyperammononemia, encephalopathy, hypothermia Xenical (orlistat)4 Xenical may increase concentrations of

Xenical may Possible effects of concomitant reduce exposure of administration of Xenical and listed drug

Cyclosporine

Amiodarone

Antiepileptic agents: increased frequency or severity of convulsions Antiretroviral agents: loss of virological control Levothyroxine: changes in thyroid function Warfarin: changes in coagulation parameters

References 1.

Belviq (lorcaserin) prescribing information. Woodcliff Lake, NJ: Eisai Inc.; 2012.

2.

Contrave (naltrexone/bupropion) prescribing information. La Jolla, CA: Orexigen Therapeutics, Inc.; 2016.

3.

Qsymia (phentermine/topiramate) prescribing information. Mountain View, CA: Vivus, Inc.; 2014.

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Weight Loss Drug Interactions See Each Agent’s Prescribing Information for Details 4.

Xenical (orlistat) prescribing information. South San Francisco, CA; Genentech USA, Inc.; 2016.

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